Katie Couric, “Modern Family” star Jesse Tyler Ferguson and “True Blood” hottie Joe Manganiello took to the digital lounge at the 2014 Stand Up To Cancer benefit to urge fans via Instagram to donate to the cause.

Stand Up To Cancer is an annual charity event to promote awareness and raise funds for cancer research.

Couric’s digital lounge was a new addition to the 2014 program, where celebrities such as Jon Hamm, Halle Berry, Jennifer Aniston and Tony Goldwyn were on hand reaching out to viewers by phone, Facebook, Instagram and other social media as part of the “We’re Calling You” campaign.

Check out the digital message above and more information about how you can help the cause can be found here.