In the world of “House,” this probably qualifies as a meet-cute: Our antihero (Hugh Laurie) taking umbrage at a diagnosis made by the prison doctor played by new series regular Odette Annable.

In a clip from the Season 8 premiere, “20 Vicodin,” a prison-bound house is making his rounds — as a trusty — and overhears Annable’s Dr. Jessica Adams prescribe something to another inmate. Naturally, he doesn’t think much of her diagnosis.

And — spoiler alert — for one of the few times in the history of the series, the correct diagnosis actually is lupus.

(Also: We don’t know why Mary Murphy is introducing this clip, the one from “Bones” and other FOX previews either. Just go with it.)

“House” premieres at 9 p.m. ET Monday, Oct. 3. What do you think of the scene?