London 1891. As the police investigate a series of gruesome murders, renowned explorer Sir Malcolm Murray (Timothy Dalton) and the strangely beautiful Vanessa Ives (Eva Green) know there’s something darker at play. In search of someone close to them who has been lost, they recruit American sharp-shooter Ethan Chandler (Josh Hartnett) and Dr. Victor Frankenstein (Harry Treadaway) to help them on their journey.