It was really the 2011 comedy "Bridesmaids" that skyrocketed her to stardom, but since then she's given side-splitting turns in "Identity Thief," "The Heat," "Tammy," "Spy" and now "The Boss." Her highly-anticipated female "Ghostbusters" movie hits theaters this summer, so it's only fitting the MTV Movie Awards honor this Comedic Genius in 2016.
After accidentally throwing her award across the stage when Kevin Hart goes to hug her, McCarthy says, "Thank you, Mr. Rock Johnson and thank you, Mr. Rock's assistant ... I don't know about the odds of keeping your job after that eff up, but we'll how it goes."
But in all seriousness, McCarthy has a laundry list of funny women to thank for getting her here.
"I may be the first woman to receive this award, but I am certainly, certainly not the first one to deserve it," says McCarthy. "I think I'm a walking human patchwork of other remarkable funny women who I have loved and studied over the years. I am only here because Carol Burnett, Jane Curtain, Phyllis Diller, Whoopi Goldberg, Teri Garr, Madeline Kahn, Lucille Ball, Gilda Radner, Julia Louis-Dreyfus, Diane Keaton, Tracey Ullman, Bette Midler, Lily Tomlin and my mom Sandy Lynn McCarthy taught me not to fear being the butt of the joke and taught me not to worry about being likable or perfect and to lovingly go for the kill."